Site-specific inhibitors of histone methyltransferase...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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Reexamination Certificate

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07875741

ABSTRACT:
The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where R1and R1is —OCH3or —OH, R2and R2is —OH or —OAc; a process of isolating compound of structural formula Ia, where R1and R1is —OCH3, R2and R2is —OH; a process of preparation of compound of structural formula Ib, where R1and R1is —OCH3, R2and R2is —OAc; a process of preparation of compound of structural formula Ic, where R1and R1is —OH, R2and R2is —OH; and use of compounds of structural formula I for manufacture of a medicament for management of cancer and/or disease conditions in a subject in need thereof.

REFERENCES:
patent: 2004189599 (2004-07-01), None
patent: 2004/189599 (2004-08-01), None
patent: 2005089304 (2005-04-01), None
patent: 2005/089304 (2005-07-01), None
patent: WO 01/37848 (2001-05-01), None
patent: WO 03/101751 (2003-12-01), None
Depsides and Depsidones as Inhibitors of HIV-1 Neamati et al., Depsides and Depsidones as Inhibitors of HIV-1 Integrase: Discovery of Novel Inhibitors through 3D Database Searching, Journal of Medicinal Chemistry (1997), 40(6), 942-951.
STN Accession No. 1997:186983.
Derwent-ACC-No. 2004-090656, Fujii H., Recording material for recording sheets comprises color-forming dye and at least one of phthalic acid, hydroxybenzoic acid, anilide, biphenyl and benzotriazole derivatives, amorphous, Patent Family WO 03101751 A1.
Derwent-ACC-No. 2001-381266, Lansky E.P., Pharmaceutical compositions useful for protecting against cancer and treating various estrogen-associated disorders comprise pomegranate seed oil and pomegranate juice, Patent Family WO 0137848 A1.

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