Site-specific incorporation of redox active amino acids into...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252330, C435S471000, C435S488000, C536S023200

Reexamination Certificate

active

07811801

ABSTRACT:
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.

REFERENCES:
patent: 7045337 (2006-05-01), Schultz et al.
patent: 2003/0082575 (2003-05-01), Schultz et al.
patent: 2003/0108885 (2003-06-01), Schultz et al.
patent: WO 02/085923 (2002-10-01), None
patent: WO 02/086075 (2002-10-01), None
patent: WO 2004/035605 (2004-04-01), None
patent: WO 2004/035743 (2004-04-01), None
patent: WO 2004/058946 (2004-07-01), None
patent: WO 2004/094593 (2004-11-01), None
patent: WO 2005/003294 (2005-01-01), None
patent: WO 2005/007624 (2005-01-01), None
patent: WO 2005/007870 (2005-01-01), None
patent: WO 2005/019415 (2005-03-01), None
Chin et al. (2003) “An Expanded Eukaryotic Genetic Code”Science, 301: 964-967.
Feng et al. (2003) “Expanding tRNA recognition of a tRNA synthetase by a single amino acid change.”Proceedings of the National Academy of Sciences USA, 100(10): 5676-5681.
Forster et al. (2003) “Programming peptidomimetic synthetases by translating genetic codes designed de novo.”Proceedings of the National Academy of Sciences USA, 100(11): 6353-6357.
Francklyn et al. (2002) “Aminoacyl-tRNA synthetases: Versatile players in the changing theater of translation.”RNA, 8: 1363-1372.
Ibba (1996) “Strategies for in vitro and in vivo translation with non-natural amino acids.”Biotechnology and Genetic Engineering Reviews, 13: 197-216.
Kiga et al. (2002) “An engineeredEscherichia colityrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system.”Proceedings of the National Academy of Sciences USA, 99(15) : 9715-9723.
Kowal et al. (2001) “Twenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria.”Proceedings of the National Academy of Sciences USA, 98(5): 2268-2273.
Liu and Schultz (1999) “Progress toward the evolution of an organism with an expanded genetic code.”Proceedings of the National Academy of Sciences USA, 96: 4780-4758.
Ohno et al. (1998) “Co-Expression of Yeast Amber Suppressor tRNAtyrand Synthetase inEscherichia coli: Possibility to Expand the Genetic Code.”J. Biochem124(6):1065-1068.
Wang and Schultz (2001) “A general approach for the generation of orthogonal tRNAs.”Chemistry and Biology, 8: 883-890.
Wang et al. (2000) “A New Functional Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins.”Journal of the American Chemistry Society, 122: 5010-5011.
Wang et al. (2001) “Expanding the Genetic Code ofEscherichia coli.” Science, 292: 489-500.
Zhang et al. (2002) “The Selective Incorporation of Alkenes into Proteins inEscherichia coli.” Angewandte Chemie, International Edition, 41: 2840-2842.
Zhang et al. (2003) “A New Strategy for the Site-Specific Modification of Proteins in Vivo.”Biochemistry, 42: 6735-6746.
Wang et al. “Addition of the Keto Functional Group to the Genetic Code ofEscherichia coli.” PNAS, 100(1):56-61 (published on-line Dec. 23, 2002).
Alfonta et al. “Site Specific Incorporation of a Redox-Active Amino Acid into Proteins.”J. Am. Chem. Soc., 125:14662-14663 (published on-line Nov. 6, 2003).
Janes et al. (1990) “A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase,”Science, 248(4958):981-987.
Rodriguez et al. (1975)“The reciprocal exclusion by L-dopa (L-3,4-dihydroxyphenylalanine) and L-tyrosine of their incorporation as single units into a soluble rat brain protein,”Biochemistry Journal, 149(1):115-121.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Site-specific incorporation of redox active amino acids into... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Site-specific incorporation of redox active amino acids into..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Site-specific incorporation of redox active amino acids into... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4157404

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.