Site specific incorporation of keto amino acids into proteins

Details Site specific incorporation of keto amino acids into proteins Site specific incorporation of keto amino acids into proteins

2011-03-22

2011-03-22

Rao, Manjunath N (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S252330, C435S069100, C536S023200

Reexamination Certificate

active

07910345

ABSTRACT:
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.

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