Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Reexamination Certificate
2008-07-15
2008-07-15
Gebreyesus, Kagnew H. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
C435S193000, C435S069100, C435S252330, C435S488000, C530S350000, C536S023100, C536S023740, C536S024100
Reexamination Certificate
active
07399619
ABSTRACT:
Translation systems and other compositions including orthogonal aminoacyl tRNA-synthetases that preferentially charge an orthogonal tRNA with an iodinated or brominated amino acid are provided. Nucleic acids encoding such synthetases are also described, as are methods and kits for producing proteins including heavy atom-containing amino acids, e.g., brominated or iodinated amino acids. Methods of determining the structure of a protein, e.g., a protein into which a heavy atom has been site-specifically incorporated through use of an orthogonal tRNA/aminoacyl tRNA-synthetase pair, are also described.
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Schultz Peter G.
Wang Lei
Wu Ning
Xie Jianming
Elrod-Erickson Monica
Gebreyesus Kagnew H.
Quine Intellectual Property Law Group P.C.
The Scripps Research Institute
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