Site-specific, covalent bioconjugation of proteins

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S391100, C530S391300, C530S402000

Reexamination Certificate

active

09820210

ABSTRACT:
Heterofunctional crosslinking groups are provided having the formula:wherein W is a covalent core component; L1, L2and L3are independently linking groups; X is a non-covalent or reversibly covalent protein tag binder; Y is a activatable covalent linking group; and Z is a protected or unprotected covalent crosslinking group.

REFERENCES:
patent: 5444150 (1995-08-01), Inman et al.
patent: 5532379 (1996-07-01), Fujimoto et al.
patent: 5601824 (1997-02-01), Hoess et al.
patent: 5840712 (1998-11-01), Morgan, Jr. et al.
patent: 5851778 (1998-12-01), Oh et al.
patent: WO00/02050 (2000-01-01), None
patent: WO 00/04382 (2000-01-01), None
Roberts et al, Basic Principles of Organic Chemistry, Second edition. Menlo Park. W.A. Bejamin, Inc. (1977), 1208-1210.
Boring, Daniel L. et al., “Trifunctional Agents as a Design Strategy for Tailoring Ligand Properties: Irreversible Inhibitors of A1Adenosine Receptors”,Bioconjugate Chem., 1991, pp. 77-88, vol. 2, No. 2, American Chemical Society.
Roberts, John D. et al.,Basic Principles of Organic Chemistry, 1977, pp. 1208-1210, W.A. Benjamin, Inc., Menlo Park, California.
Boring, Daniel L., et al. “Trifunctional Agents as a Design Strategy for Tailoring Ligand Properties: Irreversible Inhibitors of A1Adenosine Receptors”,Bioconjugate Chemistry(1991) 2(2)77-88.
Jacobson, Kenneth A., et al. “Cleavable Trifunctional' Approach to Receptor Affinity Labeling: Chemical Regeneration of Binding to A1-Adenosine Receptors”,Bioconjugate Chemistry(1995) 6(3):255-263.
Jacobson, Kenneth A., et al “Molecular Probes For Muscarinic Recepetors: Functionalized Congeners of Selective Muscarinic Antagonists”,Life Sciences(1995) 56(11/12):823-830.
Ozaki, Shoichiro, et al. “Synthesis and biological properties of 2-substitutedmyo-inositol 1,4,5-trisphosphate analogues directed toward affinity chromatography and photoaffinity labeling”,Carbohydrate Research(1992) 234(0):189-206.
Geselowitz, Daniel A., et al. “Quantitation of Triple-Helix Formation Using a Photo-Cross-Linkable Aryl Azide/Biotin/Oligonucleotide Conjugate”,Bioconjugate Chemistry(1995) 6(4):502-506.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Site-specific, covalent bioconjugation of proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Site-specific, covalent bioconjugation of proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Site-specific, covalent bioconjugation of proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3810960

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.