Site-specific conjugation of immunoglobulins and detectable labe

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303913, 5303915, 5303917, 5303919, C07K 1512, C07K 1528

Patent

active

051910667

ABSTRACT:
A process for producing a derivatized immunoglobulin and conjugates prepared therewith are provided. The derivatized immunoglobulin is produced by introducing sulfhydryl groups in the Fc region of an immunoglobulin wherein the Fab portion of the immunoglobulin is not altered. The derivatized immunoglobulin is used to prepare conjugates with various detectable moieties wherein a controlled distance exists between the Fc region of the immunoglobulin and the detectable moiety. The conjugates are particularly useful for performing immunoassays, and exhibit improved longevity, specificity and sensitivity.

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patent: 4981953 (1991-01-01), Barbieri et al.
patent: 4994385 (1991-02-01), Bieniarz et al.
O'Shannessy et al., "Labeling of the Oligosaccharide Moieties of Immunoglobulins", J. Immunol. Methods, 1987, vol. 99, pp. 153-161.

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