Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1998-02-19
1999-11-23
Clardy, S. Mark
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 9321, 424455, 4241781, 514937, A61B 5055, A61K 966, A61K 39395, A01N 4350
Patent
active
059895209
ABSTRACT:
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
REFERENCES:
patent: 5174737 (1992-12-01), Weiner et al.
patent: 5585112 (1996-12-01), Unger et al.
Urdal et al. "Tumor-associated Ganglio-N-Triosylceramide," Journal of Biological Chemistry, vol. 255, No. 21, pp. 10509-10516, 1980.
Lanza Gregory M.
Wickline Samuel A.
Barnes-Jewish Hospital
Clardy S. Mark
Hartley Michael G.
LandOfFree
Site specific binding system, imaging compositions and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Site specific binding system, imaging compositions and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Site specific binding system, imaging compositions and methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1217908