Site-directed mutagenesis modified glycoprotein hormones and met

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530399, 536 235, 536 2351, C12N 1518, C07K 1300

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active

057054797

ABSTRACT:
Described are new glycoprotein hormones capable of competing with natural hormones for the normal receptor binding sites but substantially incapable of effecting post receptor activities. The glycoprotein hormones of the present invention have had specific (rather than all) oligosaccharide chains removed so as to effectively diminish biologic activity while not significantly reducing plasma half-life, thus improving the molecules effectiveness as an antagonist compared with conventionally-produced molecules. The preferred glycoprotein hormones are ideally obtained by site-directed mutagenesis to selectively deglycosylate the protein. Also described are therapeutic treatments comprising the administration of the recombinant glycoprotein hormones of the present invention as hormone antagonists.

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