Site-directed mutagenesis modified DNA encoding glycoprotein hor

Details Site-directed mutagenesis modified DNA encoding glycoprotein hor Site-directed mutagenesis modified DNA encoding glycoprotein hor

1993-09-23

1994-10-04

Hill, Jr., Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 435 691, 435 694, 4353201, 4352523, 530399, C12N 1518

Patent

active

053527798

ABSTRACT:
Described are new glycoprotein hormones capable of competing with natural hormones for the normal receptor binding sites but substantially incapable of effecting post receptor activities. The glycoprotein hormones of the present invention have had specific (rather than all) oligosaccharide chains removed so as to effectively diminish biologic activity while not significantly reducing plasma half-life, thus improving the molecules effectiveness as an antagonist compared with conventionally-produced molecules. The preferred glycoprotein hormones are ideally obtained by site-directed mutagenesis to selectively deglycosylate the protein. Also described are therapeutic treatments comprising the administration of the recombinant glycoprotein hormones of the present invention as hormone antagonists.

REFERENCES:
patent: 4868119 (1989-09-01), Clark et al.
patent: 4879227 (1989-11-01), Clark et al.
patent: 5260421 (1993-11-01), Chappel et al.
Slbok et al Biochemistry 26: 3650 (1987).
Matzuk et al J. Cell Biol 106:1049 (1988).
Matzuk et al J Biol Chen 264:2409 (1989).

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