Site-directed chemotherapy of metastases

Details Site-directed chemotherapy of metastases Site-directed chemotherapy of metastases

1997-06-26

2000-06-13

Huff, Sheela

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

424 149, 4241821, 4241831, 514 23, 436827, A61K 39395

Patent

active

060746432

ABSTRACT:
Provided for use in site-directed chemotherapy are compositions comprising chemotherapeutic agents targeted to either arrested metastatic cells via a cell-surface marker associated with metastasis; or are targeted to type 1 endothelial cells of the tissue comprising the organ site at which metastatic cells arrest such that (a) any arrested metastatic tumor cells are then exposed to the chemotherapeutic agent, and/or (b) the endothelial cells are altered thereby inhibiting the ability of the metastatic tumor cells to arrest, survive or proliferate in that site. Also provided are methods of site-directed chemotherapy of metastatic cells of non-lymphoid tumor origin. Site-directed chemotherapy comprises introducing a therapeutically effective amount of a chemotherapeutic agent directly into a vascular access of the organ having, or suspected of having, arrested metastatic cells thereby concentrating the therapy in the prometastatic territories of the treated organ.

REFERENCES:
patent: 5639737 (1997-06-01), Rubin
Lazzaro, et al., Experimental Hematology, vol. 23, pp. 1347-1352, 1995.

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