Sintering process for producing thin films of calcium phosphate

Details Sintering process for producing thin films of calcium phosphate Sintering process for producing thin films of calcium phosphate

1997-10-30

1998-06-16

Dudash, Diana

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Implantable permanent prosthesis

427 211, 427 212, 4273761, B05D 302, B05D 500

Patent

active

057666695

ABSTRACT:
An improved process for producing a thin film of calcium phosphate entities to support bone cell activity thereon. The material to be sintered is prepared by combining a solution of ammonium phosphate with a solution of calcium nitrate to form a sol-gel containing hydroxyapatite. A film of the sol gel is applied to at least one side of the substrate and the film coated on the substrate is sintered to form a solid film of calcium phosphate entities. The improvement in the process comprising sintering the film at temperatures selected from a range of temperatures which optimize a composition of calcium phosphate entities in the film. The sintering step converts hydroxyapatite to .alpha.-tricalcium phosphate where extent of such conversion is temperature dependent. The optimized composition comprises a ratio of hydroxyapatite to .alpha.-tricalcium phosphate in the range of 50:50 to 20:80. A sintering temperature is selected to provide these ratios. The sintering temperature is selected from a range of 920.degree. C. up to 1100.degree. C. where the higher the select temperature, the greater the amount of .alpha.-tricalcium phosphate in the ratio.

REFERENCES:
patent: 4871578 (1989-10-01), Adam et al.
patent: 4983182 (1991-01-01), Kijima et al.
patent: 4988362 (1991-01-01), Toriyama et al.
patent: 4990163 (1991-02-01), Ducheyne et al.
patent: 5030474 (1991-07-01), Saito et al.
patent: 5077079 (1991-12-01), Kawamura et al.
patent: 5128169 (1992-07-01), Saita et al.
patent: 5141576 (1992-08-01), Shimamune et al.
patent: 5266248 (1993-11-01), Ohtsuka et al.
"The effect of substrate composition and condition on resorption by isolated osteoclasts", Bone and Mineral, 6 (1989), pp. 261-275, Shimizu, et al. (no month).
"An Assay System Utilizing Devitalized Bone for Assessment of Differentiation of Osteoclast Progenitors", Journal of Bone and Mineral Research, vol. 7, No. 3, 1992, pp. 321-328, Amano, et al. (Mar.).
"Resorption Of Bone By Isolated Rabbit Osteoclasts", J. Cell. Sci. 66, 1984, pp. 383-399, Chambers, et al. (no month available).
"Failure of Cells of the Mononuclear Phagocyte Series to Resorb Bone", Calcif Tissue Int. (1984) 36, pp. 556-558, Chambers, et al. (no month).
"The resorption of biological and non-biological substrates by cultured avian and mammalian osteoclasts", Ana. Embryo (1984) 170, pp. 247-256, Jones, et al. (no month).
"Resorption of Dentine by Isolated Osteoclasts in vitro", Br. Dent J.1984, pp. 216-219, Boyde, et al. (no month available).

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