Sinomenine derivatives and preparation and uses thereof

Details Sinomenine derivatives and preparation and uses thereof Sinomenine derivatives and preparation and uses thereof

2011-04-26

2011-04-26

Desai, Rita J (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S074000

Reexamination Certificate

active

07932264

ABSTRACT:
The present invention relates to the preparation and pharmacological use of sinomenine derivatives of formula I. The approach disclosed herein is the modification of D ring by-substituting for R. Additional substitutions in the other rings are also provided herein. Several of the sinomenine derivatives have significantly greater anti-inflammation activity when compared with the parent compound.

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