Sinister-3,5-disubstituted oxozolidines their preparation and us

Details Sinister-3,5-disubstituted oxozolidines their preparation and us Sinister-3,5-disubstituted oxozolidines their preparation and us

1974-12-04

1977-09-27

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D26304

Patent

active

040511448

ABSTRACT:
Preparation of S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents using as starting material an optically active alkalmine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO-where R is hydrogen or an alkali metal)-1,2,5-thiadiazole. Certain3-morpholino-4-chloro(or RO-)-1,2,5-thiadiazoles and certain alkamines and their preparation also are described. Preferred alkamines are S-3,5-disubstituted oxazolidines.

REFERENCES:
patent: 2964530 (1960-12-01), Zenitz
patent: 3160634 (1964-12-01), Hodge
Bergmann et al. C.A. 15, 3277-3279 (1921).

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