Single-vessel process for preparing ring-substituted n-alkylanil

Details Single-vessel process for preparing ring-substituted n-alkylanil Single-vessel process for preparing ring-substituted n-alkylanil

1984-05-10

1985-09-10

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C10204, C07C10206, C07C10202, C07C10200

Patent

active

045408165

ABSTRACT:
Process for preparing ring-substituted N-alkylanilines of the formula (1) ##STR1## in which R.sub.1 and R.sub.2 each denote methyl or ethyl, in a single vessel, which comprises acylating m-nitroaniline in an excess of an aliphatic carbonyl compound of the formula (2) ##STR2## in which R.sub.1 is as defined above, with an acylating agent which contains the --CO--R.sub.2 acyl radical--which is transferred-- and reductively alkylating the resulting compound of the formula (3) ##STR3## in which R.sub.2 is as defined above, at temperatures of 120.degree.-160.degree. C. under a hydrogen pressure of 20-150 bar without intermediate isolation through the presence of an acid reaction promoter and of a nickel catalyst.

REFERENCES:
patent: 3857886 (1974-12-01), Hensel et al.
patent: 3919269 (1975-11-01), Jaffe et al.
patent: 3960886 (1976-06-01), Schulenberg
patent: 4144270 (1979-03-01), Neri et al.

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