Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-11-28
2006-11-28
Navarro, Mark (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S006120
Reexamination Certificate
active
07141658
ABSTRACT:
The invention concerns single stranded oligonucleotides comprising a sequence of at least 12 consecutive nucleotide motifs contained in one of the sequences SEQ ID NO: 1 to SEQ ID NO: 4 wherein “n” represents an identical or different nucleotide selected among inosine or an equimolar mixture of 4 different nucleotides selected among a, t, c or g, and among oligonucleotides complementary thereto. The invention also concerns using the oligonucleotides to detect bacteria of the Spirochaetales order. The invention is based on the use of specifically defined sequences in the rpoB gene of spirochetes coding for the beta subunit of the bacterial RNA polymerase.
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Alekshun et al., “Molecular cloning and characterization of Borrelia burgdoferi rpoB”, Gene: An International Journal on Genes and Genomes and Genomes, GB, Elsevier Science Publishers, Barking, vol. 186, No. 2, Feb. 28, 1997, pp. 227-235, XP004093305.
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Renesto et al., “ropB gene analysis as a novel strategy for identification of spirochetes from the genera Borrelia, Treponema, and Leptospira”, Journal of Clinical Microbiology, vol. 38, No. 6, Jun. 2000, pp. 2200-2203, XP002155811.
Drancourt Michel
Raoult Didier
bioMerieux
Navarro Mark
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