Single-stranded labelled oligonucleotides, reactive monomers and

Details Single-stranded labelled oligonucleotides, reactive monomers and Single-stranded labelled oligonucleotides, reactive monomers and

1987-05-04

1990-08-14

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, 435 6, 935 77, 935 78, C07H 19073, C07H 1910, C07H 19173, C07H 1920

Patent

active

049488821

ABSTRACT:
Substantially pure single-stranded oligonucleotides having a preselected sequence of not more than about 200 nucleotides, at least one of which is at a preselected position in the sequence and includes a base with a covalently attached linker arm containing or capable of binding at least one reporter group or solid support. A process for the chemical synthesis of the substantially pure single-stranded oligonucleotide and modified nucleosides useful in such synthesis are provided.

REFERENCES:
patent: 4500707 (1985-02-01), Caruthers et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4711955 (1987-12-01), Wand et al.
D. E. Draper, Nucleic Acids Research, 12(2), 989-1002 (1984).

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