Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-10-20
1999-02-02
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
2504591, 359396, C12Q 168, G02B 2134, G01J 158
Patent
active
058663312
ABSTRACT:
Disclosed are methods for accurately determining the total emission intensity of a single fluorochrome, under imaging conditions, using a digital imaging fluorescence microscopy system. Also disclosed are methods for detecting and localizing probe-target molecule binding. The detection method has sufficient resolution and sensitivity to locate and detect a single target-bound probe.
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Femino Andrea M.
Singer Robert H.
Chambers Jasemine C.
Priebe Scott D.
University of Massachusetts
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