Single-loop chromatography system and method

Details Single-loop chromatography system and method Single-loop chromatography system and method

1989-05-03

1992-02-25

Silverman, Stanley S.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

2101982, 210656, 7386422, B01D 3508, G01N 2506

Patent

active

050910922

ABSTRACT:
Automated gel permeation chromatography of multiple individual samples is effected with high precision and high speed utilizing a common sample sizing loop into which each sample is placed prior to its injection into the chromatography column, thereby eliminating the need for precisely matched sample loops. Each sample is pre-stored in its own container, the containers being automatically sequentially accessed to feed a portion of the contained sample medium to the common sample sizing loop. The common sample flow path, including the sample sizing loop is automatically cleaned with rinse solvent between loading of successive samples into the sizing loop. Multiple programs may be employed to control the processing times for different types of sample fluid. A sample container closure member having a unique sealing insert member is provided to preclude leakage of fluid from the sample storage container when the container is pressurized.

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patent: 4604363 (1986-08-01), Newhouse et al.
patent: 4674323 (1987-06-01), Rulf et al.

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