Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1978-09-05
1981-01-13
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 422 61, 424 12, G01N 3348, A61K 4300, B01T 100
Patent
active
042449405
ABSTRACT:
This invention provides a two-site immunoassay method for a ligand utilizing a single incubation. The multivalent ligand, labeled receptor for the ligand and unlabeled receptor for the ligand covalently bound to a solid-phase support are incubated as a substantially stable suspension to produce a solid and liquid phase. The solid and liquid phases are separated from each other and the labeled receptor in either phase is quantitated.
The method may be used to assay for human thyroid stimulating hormone using purified, radioactively labeled antibodies and unlabeled antibodies covalently bound to hydrolyzed polyacrylamide particles.
REFERENCES:
patent: 3555143 (1971-01-01), Axen et al.
patent: 3853987 (1974-12-01), Dreyer
patent: 3995019 (1976-11-01), Jerome
patent: 4017597 (1977-04-01), Reynolds
patent: 4034073 (1977-07-01), Weetalc
patent: 4088746 (1978-05-01), Blakemore et al.
Abraham, Ed, Handbook of Radioimmuno Assay, Marcel Dekker, Inc., N.Y., 1977, pp. 131-134.
Radioimmuno Assay and Related Procedures in Medicine, International Atomic Energy Agency, Vienna, 1974, pp. 131-147, 149-164.
Woodhead et al., Br. Med. Bull., vol. 30, No. 1, 1974, pp. 44-49.
Blakemore Judith I.
Jeong Henry J.
Lewin Nathan
Bio-Rad Laboratories, Inc.
Nucker Christine M.
Padgett Benjamin R.
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