Single gene encoding aortic-specific and striated-specific muscl

Details Single gene encoding aortic-specific and striated-specific muscl Single gene encoding aortic-specific and striated-specific muscl

1997-02-06

1998-12-08

Degen, Nancy

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 701, 4353201, 435325, 536 231, 536 241, C12P 2102, C12N 1585, C12N 1511, C07H 2104

Patent

active

058467734

ABSTRACT:
Aortic-preferentially-expressed gene-1 (APEG-1) and striated muscle preferentially expressed (SPEG) polypeptide, DNA sequences encoding and controlling the transcription of the APEG-1/SPEG encoding gene, methods of diagnosing vascular injury, methods of conferring smooth muscle-cell specific expression, and methods of inhibiting vascular smooth muscle cell proliferation by increasing the level of APEG-1 at the site of vascular injury.

REFERENCES:
Blobel et al., "Structure, Function and Evolutionary Relationship of Proteins Containing a Distintegrin Domain", Curr. Opin. Cell Biol., 4:760-65 (1992).
Del Sal et al., "The Growth Arrest-Specific Gene, gas1, Is Involved in Growth Suppression", 1992, Cell,70:595-607 (1992).
Gallagher et al., "The Carboxyl Terminus of the Smooth Muscle Myosin Light Chain Kinase Is Expressed as an Independent Protein, Telokin", J. Biol. Chem., 266:23945-52 (1991).
Gorski et al., "Molecular Cloning of a Diverged Homeobox Gene That Is Rapidly Down-Regulated During the G.sub.0 /G.sub.1 Transition in Vascular Smooth Muscle Cells", Mol. And Cell. Biol., 13:3722-33 (1993).
Holden, et al., "X-ray Structure Determination of Tekokin, the C-terminal Domain of Myosin Light Chain Kinase, at 2.8 .ANG. Resolution", J. Mol. Biol., 277:840-51 (1992).
Hunter et al., "Targeting Gene Expression to Specific Cardiovascular Cell Types in Transgenic Mice", Hypertension, 22:608-17 (1993).
Hynes, "Integrins: Versatility, Modulation, and Signaling in Cell Adhesion", Cell, 69:11-25 (1992).
Kozak, "At Lease Six Nucleotides Preceding the AUG Initiator Codon Enhance Translation in Mammalian Cells", J. Mol. Biol., 196:947-50 (1987).
Leco et al., "Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) Is an Extracellular Matrix-associated Protein with a Distinctive Pattern of Expression in Mouse Cells and Tissues", J. Biol. Chem., 269:9352-60 (1994).
Pauly et al., "Experimental Models That Mimic the Differentiation of Vascular Cells", Circulation (Supp III), 86:III-68-73 (1992).
Hsieh et al., "APEG-1, a Novel Gene Preferentially Expressed in Aortic Smooth Muscle Cells, is Down-regulated by Vascular Injury," FASEB J., 10:6, p. A1012, No. 74 (1996).
Hsieh et al., "APEG-1, A Novel Gene Preferentially Expressed In Aortic Smooth Muscle Cells, is Down-regulated by Vascular Injury," J. Biol. Chem. (Microfilms) 271(29):17354-59 (1996).
McGeoch et al., "Complete DNA Sequence of the Short Repeat Region in the Genome of Herpes Simplex Virus Type I," Nucleic Acids Research 14(4):1727-1745 (1986).
EMBL EST, Accession No. R24327, Sequence reference yg32f04.rl, 23-Apr-1995, Homo sapiens cDNA clone 33988 5'XP002014921.
EMBL EST, Accession No. W55328, Sequence reference mb12e01.rl, 06-Jun-1996, Life Tech mouse brain, Mus musculus cDNA clone 319992 5'XP002014922.
Ross, "The Pathogenesis of Atherosclerosis: A Perspective for the 1990s", Nature, 362:801-809 (1993).
Ruoslahti et al., "New Perspectives in Cell Adhesion: RGD and Integrins", Science, 238:491-96 (1987).
Shanahan et al., "Isolation of Gene Markers of Differentiated and proliferating Vascular Smooth Muscle Cells", CIRCULATION RES., 73:193-204 (1993).
Sun et al., "Molecular Cloning of Five Messenger RNAs Differentially Expressed in Preneoplastic or Neoplastic JB6 Mouse Epidermal Cells: One Is Homologous to Human Tissue Inhibitor of Metalloproteinases-3", Cancer Res., 54;1139-44.

Affiliated with

Also associated with

Rating

Single gene encoding aortic-specific and striated-specific muscl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Single gene encoding aortic-specific and striated-specific muscl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Single gene encoding aortic-specific and striated-specific muscl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-176204