Single chain recombinant T cell receptors

Details Single chain recombinant T cell receptors Single chain recombinant T cell receptors

2003-10-03

2009-08-04

Ewoldt, G. R (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C436S501000

Reexamination Certificate

active

07569664

ABSTRACT:
A single chain T cell receptor (scTCR) comprising an a segment constituted by a TCR α chain variable region sequence fused to the N terminus of a TCR α chain constant region extracellular sequence, a β segment constituted by a TCR β chain variable region fused to the N terminus of a TCR β chain constant region extracellular sequence, and a linker sequence linking the C terminus of the α segment to the N terminus of the β segment, or vice versa, the constant region extracellular sequences of the α and β segments being linked by a disulfide bond, the length of the linker sequence and the position of the disulfide bond being such that the variable region sequences of the α and β segments are mutually orientated substantially as in native αβ T cell receptors. Complexes of two or more such scTCRs, and use of the scTCRs in therapy and in various screening applications are also disclosed.

REFERENCES:
patent: WO 96 18105 (1996-06-01), None
patent: WO 99 18129 (1999-04-01), None
patent: WO 99/60120 (1999-11-01), None
patent: WO 00 31239 (2000-06-01), None
Chung et al. “Functional Three-Domain Single-Chain T-Cell Receptors”; Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, US.; vol. 91, No. 26, Dec. 20, 1994, pp. 12654-12658, XP002039051.

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