Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-11-03
1995-11-28
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 530397, 530399, 530850, A61K 3822, C07K 14575
Patent
active
054708265
ABSTRACT:
Polypeptides exhibiting an inhibitory action over follitropin are disclosed. These polypeptides are designated follitropin suppressing proteins, or "FSP's," and range in size from 30 to 60 kD as determined by SDS-PAGE. Uses for FSP's, including regulation of fertility and as immunogens, are disclosed.
REFERENCES:
patent: 4215130 (1980-07-01), Sjoerdsma
patent: 4585754 (1986-04-01), Meisner et al.
patent: 4833128 (1989-05-01), Solomon et al.
patent: 5037805 (1991-08-01), Ling
patent: 5041538 (1991-08-01), Ling et al.
Naoto Ueno, Nicholas Ling, Shao-Yao Ying, Frederick Esch, Shunichi Shimasaki, and Roger Guillemin, "Isolation and Partial characterization of Follistatin: A Single-Chain M.sub.r 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone" Proc. Natl. Acad. Sci. USA, vol. 84, pp. 8282-8286, Dec. 1987.
Shao-Yao, Ann Becker, Geoff Swanson, Phil Tan, Nocholas Ling, Fred Esch, Naoto Ueno, Shunichi Shimasaki, and Roger Guillemin, "Follistatin Spcifically Inhibits Pituitary Follicle Stimulating Hormone Release In Vitro," Biochemical and Biophysical Research Communications, vol. 149, No. 1, 1987, Nov. 30, 1987, pp. 133-139.
D. M. Robertson, R. Klein, F. L. De Vos, R. I. McLachlan, R. E. H. Wettenhall, M. T. W. Hearn, H. G. Burger and D. M. de Krester, "The Isolation of Polypeptides with FSH Suppresing Activity from Bovine Follicular Fluid which are Structurally Different to Inhibin", Biochemical and Biophysical Research Communications, vol. 149, No. 2 1987, Dec. 16, 1987, pp. 744-749.
L. J. Leversha, D. M. Robertson, F. L. de Vos, F. J. Morgan, M. T. W. Hearn, R. E. Wettenhall, J. K. Findlay, H. G. Burger and D. M. de Krester, "Isolation of Inhibin from Ovine Follicular Fluid", 1987 Journal of Endocrinology Ltd. pp. 213-221.
Tsonis, C. G. & Sharpe, R. M., "Dual gonadal control of follicule-stimulating hormone", Nature (1986), 321, 724-725.
Robertson, D. M., de Vos, F. L., Foulds, L. M., McLachlan, R. I., Burger, H. G., Morgan, F. J., Hearn, M. T. W., & de Kretser, D. M., "Isolation of a 31kDa form of inhibin from bovine follicular fluid", Mol. Cell Endocrin. (1986), 44, 271-277.
Ling, N., Ying, S., Ueno, N., Shimasaki, S., Esch, F., Hotta, M. and Guillemin, R., "Pituitary FSH is released bvy a heterodimer of the B-subunits from the two forms of inhibin" Nature (1986), 321, 779-782.
Vale, W., Rivier, J., Vaughan, J., McClintock, R., Corrigan, A., Woo, W., Karr, D. & Spiess. J., "Purification & characterisation of an FSH releasing protein from porcine ovarian follicular fluid" Nature (1986), 321, 776-779.
Laemmli, U. K., "Cleavage of structural proteins during the assembly of the head of bacteriophage T4", Nature (1970) 227, 680-685.
Hunkapiller, M. W., Lujan, E., Ostrander, F. & Hood L., "Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis", Methods in Enzymology (1983) 91, 227-236.
Zimmerman, C. L., Appella, E. & Pisano J. J., "Rapid analysis of amino acid phenylthiohydantoins by high-performance liquid chromatography", Analytical Biochemistry (1977), 77, 569-573.
Scott, R. S., Burger H. G. & Quigg, H. "A simple & rapid in-vitro bio-assay for inhibin", Endocrinology (1980), 107, 1536-1542.
McLachlan, R. I., Robertson, D. M., Burger, H. Q. & de Kretser, D. M. "The radioimmunossay of bovine & human follicular fluid & serum inhibin", Mol. Cell. Endocrin. (1986), 46, 175-185.
McLachlan, R. I., Robertson, D. M., Healy, D. L., Burger, H. G. & de Kretser, D. M., "Circulating immunoreactive inhibin levels during the normal human menstrual cycle" J. Crin. Endocrin (1987), 65, 5, 954-961.
McLachlan, R. I., Robertson, D. M., de Kretser, D. M. & Burger H. O., "Inhibin-a non-steroidal regulator of pituitary follicle stimulating hormone", Baillere's Clinical Endorinology & metobolism (1987) 1,1, 89-112.
Roberts, A. B., Sporn, M. B., "Transforming growth factors", Cancer Surveys (1985), 4,4, 683-705.
Cate, R. L., Mattaliano, R. J., Hession, C., Tizard, R., Forbes, N. M. Cheng, A., Ninta, E. G., Frey, A. Z., Gash, D. J., Chow, E. P., Fisher, R. A., Bertonis, J. M., Torres, G., Wallner, B. P., Ramacharndran, K. L., Ragin, R. C., Manganaro, T. F., McLaughlin, D. T. & Donohoe, P. K., "Isolation of the bovine & human genes for Mullerian inhibiting sustance & expression of the human gene in animal cells" Cell. (1986), 45, 688-698.
Kauppila, K., Cantell, K., Janne, O., Kokko, E., & Vihko, R., "Serum sex steroid & peptide hormone concentrations & endometrial estrogen & progestin receptor levels during adminastration of human leucocyte interferon" Intl. J. Cancer (1982), 29, 291-294.
Orava, M., Cantell, K. & Vihko, K., "Human leukocyte interferon inhibits human chorionic gonadotropin stimulated testosterone production by porcine leydig cells in culture", Biochemical & Biophysical Research Communications (1985), 127, 3, 809-815.
Farnworth, P. G., Robertson, D. M., de Kretser, D. M. & Burger, H. G. "Effects of 31 kilodalton bovine inhibin on follicle stimulating hormone & luteinizing hormone in rat pituitary cells in vitro: Actions under basal conditions", Endocrinology (1988) 122, 1, 207-213.
Burger Henry G.
de Kretser David M.
De Vos Fiona
Hearn Milton T. W.
McLachlan Robert I.
Biotechnology Australia Pty Ltd.
Monash Medical Centre
Monash University
Russel Jeffrey E.
St. Vincent's Institute of Medical Research
LandOfFree
Single chain proteins with FHS suppressing activity isolated fro does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Single chain proteins with FHS suppressing activity isolated fro, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Single chain proteins with FHS suppressing activity isolated fro will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2013688