Single-chain polypeptides comprising troponin I and troponin C

Details Single-chain polypeptides comprising troponin I and troponin C Single-chain polypeptides comprising troponin I and troponin C

2006-07-18

2006-07-18

Wax, Robert A. (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C436S015000

Reexamination Certificate

active

07078486

ABSTRACT:
This invention relates to single-chain polypeptides and their genetic sequences comprising human cardiac troponin I and troponin C. The single-chain polypeptide may be expressed recombinantly, and a linker peptide may be interposed between the troponin sequences. A linker peptide of about 6 to about 30 amino acids is preferred. The single-chain polypeptide has utility as a control or calibrator for troponin assays, for the purification of troponin subunits and as an antigen for the preparation of antibodies.

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