Single-chain polypeptides comprising creatine kinase M and creat

Details Single-chain polypeptides comprising creatine kinase M and creat Single-chain polypeptides comprising creatine kinase M and creat

1998-02-05

1999-11-09

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4353201, 4352523, 435325, 536 232, C12N 912, C12N 1500, C12N 120, C07H 2104

Patent

active

059812494

ABSTRACT:
This invention relates to single-chain polypeptides and their genetic sequences comprising creatine kinase M and creatine kinase B. The single-chain polypeptide may be expressed recombinantly. A linker peptide may be interposed between the creatine kinase sequences. A linker peptide of about 6 to about 50 amino acids is preferred. The single-chain polypeptide has utility as a control or calibrator for creatine kinase MB assays, for the purification of creatine kinase antibodies, and as an antigen for the preparation of antibodies.

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