Single-chain hepatocyte growth factor variants

Details Single-chain hepatocyte growth factor variants Single-chain hepatocyte growth factor variants

1992-05-18

1994-05-31

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530399, 536 2351, C12P 2106, A61K 3736

Patent

active

053169212

ABSTRACT:
The invention concerns hepatocyte growth factor (HGF) variants that are resistant to proteolytic cleavage by enzymes capable of in vivo conversion of HGF into its two-chain form. The single-chain HGF variants, which preferably have an amino acid alteration at or adjacent to any of amino acid positions 493, 494, 495 and 496 of the wild-type human HGF sequence, retain their ability to bind the HGF receptor.

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