Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-11-17
2000-08-15
Spector, Lorraine
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 435360, 4353651, 4352523, 4353201, 4241921, 4241981, 530397, 530398, 935 10, 536 234, C12N 1516, C07K 1459, C07K 1900
Patent
active
061035017
ABSTRACT:
Single-chain agonists and/or antagonists of the glycoprotein hormones are disclosed. These proteins are of the formula
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Enhanced Stimulation of Follicle Maturation and Ovalatory Potential by Long Acting Follicle-Stimulating Hormone Agonists with Extended Carboxyl-Terminal Peptides, Philip S. LaPolt, et al., Endocrinology (1992) 131:2514-2520.
Design of a Long-Acting Follitropin Agonist by Fusing the C-Terminal Sequence of the Chorionic gonadotropin .beta. subunit to the Follitropin .beta. Subunit, Fuad A. Fares, et al., Proc Natl Acad Sci USA (1992)89:4304-4308.
Crystal Structure of Human Chorlonic Gonadotropin, A.J. Lapthorn, et al., Nature (1994) 369:455-461.
Structure of Human Chorionic Gonadotropin at 2.6 A Resolution From MAD Analysis of the Selecomethionyl Protein, Hao Wu, et al., Structure (1994) 2:545-558.
A Clasped Embrace, Dinshaw J. Patel, Nature (1994)369:438-439.
Boime Irving
Menahem David Ben
Spector Lorraine
Washington University
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