Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Reexamination Certificate
2008-07-15
2008-07-15
O'Hara, Eileen B. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
C530S350000, C530S402000, C530S403000
Reexamination Certificate
active
07399838
ABSTRACT:
A recombinant polypeptide and nucleic acid constructs capable of expressing the recombinant polypeptide are provided. The recombinant polypeptide comprises a chimeric polypeptide including an antigenic peptide being capable of binding a human MHC class I, a functional human β-2 microglobulin and a functional human MHC class I heavy chain.
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Parker et al, “Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2”,J Immunol., 149(11):3580-7, 1992.
Lone et al, “In vitro induction of specific cytotoxic T lymphocytes using recombinant single-chain MHC class I/peptide complexes”,J Immunother., 21(4):283-94,1998.
Lee et al, “Functional cell surface expression by a recombinant single-chain class I major histocompatibility complex molecule with a cis-active beta 2-microglobulin domain”,Eur J Immunol., 24(11):2633-9, 1994.
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O'Hara Eileen B.
Technion Research & Development Foundation Ltd.
VanderVegt F. Pierre
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