Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-10-28
1997-03-04
Adams, Donald E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435 691, 435 697, 435 911, 5303871, 5303875, 5303877, 5303881, 5303888, 5303905, 530866, 530867, 536 2353, C12N 1562, A61K 3900, A61K 5110, C07K 1628
Patent
active
056080395
ABSTRACT:
This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.
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Brinkmann Ulrich
FitzGerald David
Pai Lee
Pastan Ira
Willingham Mark
Adams Donald E.
The United States of America as represented by the Secretary of
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