Single chain antibodies specific to VEGF receptors

Details Single chain antibodies specific to VEGF receptors Single chain antibodies specific to VEGF receptors

1997-06-02

1999-02-23

Loring, Susan A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

53038822, C12P 2108, C07K 1600

Patent

active

058745424

ABSTRACT:
Monoclonal antibodies that specifically bind to an extracellular domain of a VEGF receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.

REFERENCES:
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Terman et al., Oncogene 6:1677-1683 (1991).
Plate, et al., Nature 359, 845-848 (Oct. 1992).

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