Optical waveguides – Optical waveguide sensor
Reexamination Certificate
2005-08-18
2010-02-02
Rahll, Jerry T (Department: 2874)
Optical waveguides
Optical waveguide sensor
Reexamination Certificate
active
07657133
ABSTRACT:
An apparatus for single analyte molecule detection includes: a light source (20) for generating excitation light; a dichroic mirror (22) disposed on a first path of excitation light generated by the light source, wherein the mirror directs excitation light into a fiber aligner (30); an optical transducer coupled to the light source by the fiber aligner, the optical transducer comprising an optical waveguide (40) made of dielectric material having a first dielectrical index; a photon detector (70) disposed to receive fluorescent back radiation, wherein when a test solution having a second dielectric index lower than the first index is provided and comprises one or more target molecules, excitation light is transmitted by the waveguide and exits a waveguide tip disposed in the test solution so as to excite one or more target molecules; subsequently, the waveguide transmits back radiation along a second path to the photon detector that detects the transmitted back radiation.
REFERENCES:
patent: 5141312 (1992-08-01), Thompson et al.
patent: 0383912 (1990-08-01), None
patent: 2005002444 (2005-01-01), None
Golden, J.P. et al, “Fluorometer And Tapered Fiber Optic Probes For Sensing In The Evanescent Wave” in Optical Engineering, Soc. of Photo-Optical Instrumentation Engineers. Bellingham, US, vol. 31, No. 7, Jul. 1, 1992, pp. 1458-1462.
Thompson, R.B. et al, “Component Selection for Fiber-Optic Fluorometry” in Applied Spectroscopy, The Society For Applied Spectroscopy, Baltimore, US, vol. 44, No. 1, Jan. 1990, pp. 117-122.
Harms, Greg S. et al, “Probing conformational changes of gramicidin ion channels by single-molecule patch-clamp fluoresscence microscopy” in Biophysical Journal, NY, US, vol. 85, No. 3, Sep. 2003, pp. 1826-1838.
Calame Michel
Haas Philippe
Hecht Bert
Hegner Martin
Wild Andreas
Natzmer Joyce von
Pequignot & Myers LLC
Rahll Jerry T
University of Basel
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