Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1989-08-17
1992-02-25
Stone, Jacqueline
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 91, 4351723, 4352351, 4352402, 4353201, 435948, 536 27, 935 32, 935 57, 935 60, 935 70, C12P 2100, C12P 1934, C12N 1500, C12N 700
Patent
active
050913093
ABSTRACT:
The present invention relates to RNA vectors comprising Sindbis virus DI RNA having inserted therein heterologous RNA. The vectors of the present invention provide for the cloning and expression of heterologous RNA in eucaryotic cells as well as the packaging of heterologous RNA into viral particles in the presence of helper virus. Transformed cells and genetically altered alphavirus particles comprising alphavirus DI RNA having inserted therein heterologous RNA are also provided.
REFERENCES:
patent: 4719177 (1988-01-01), Baltimore et al.
Mackett et al. (1984), Journal of Virology, vol. 49, pp. 857-864.
Monroe et al. (1982), Journal of Virology, vol. 41, pp. 153-162.
R. Levis et al., Cell 44:137 (1986).
C. Xiong et al., Science 243:1188 (1989).
R. Levis et al., Proc. Natl. Scad. Sci. U.S.A. 84:4811 (1987).
Huang Henry V.
Levis Robin
Schlesinger Sondra
Tsiang Manuel
Weiss Barbara
Stone Jacqueline
Wang Gian
Washington University
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