Sindbis virus expression system for recombinant antibody product

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 696, 435 701, 4351723, 4352351, 435326, 435348, C12P 2106, C12P 2104, C12N 1500, C12N 700

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058437126

ABSTRACT:
This invention provides a method of expressing a multimeric polypeptide. This invention also provides a method of expressing biologically active recombinant antibodies. This invention also provides an expression cell line capable of producing multimeric polypeptides or biologically active recombinant antibodies. This invention also provides methods of producing biologically active recombinant antibodies or multimeric polypeptides. This invention also provides a transgenic animal comprising the expression cell line capable of producing biologically active recombinant antibodies or multimeric polypeptides. Also, this invention provides a method for preventing infectious diseases associated with arthropods.

REFERENCES:
patent: 5217879 (1993-06-01), Huang et al.
Bowdish, K., et al. (1991) "Yeast expression of a catalytic antibody with chorismate mutase activity." J. Biol. Chem. 266: 11901-11908 (Exhibit C).
Carroll, A.R., et al. (1992) "Synthesis and secretion of a functional antibody in a vaccinia virus expression system." Molecular Immunol. 29:821-827 (Exhibit D).
Coloma, M. J., et al. (1992) "Novel vector for the expression of antibody molecules using variable regions generated by polymerase chain reaction." J. Immunol. Methods 152:89-104 (Exhibit E).
Cheng, E.H.-Y., et al. (1996) "Bax-independent inhibition of apoptosis By Bcl-X." Nature 379:554-556 (Exhibit F).
Hasemann, C.A. and Capra, J.D. (1990) "High level production of a functional immunoglobulin heterodimer in a baculovirus expression system." Proc. Natl. Acad. Sci USA 87:3942-3946 (Exhibit G).
Hahn, C.S., et al. (1992) "Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation." Proc. Natl. Acad. Sci. USA 89: 2679-2683 (Exhibit H).
Hertz, J. and Huang, H.V. (1992) "Utilization of heterologous alphavirus junction sequences as promoters by Sindbis virus." J. Virol. 66: 491-496 (Exhibit I).
Horwitz, A.H., et al. (1988) "Secretion of functional antibody and Fab fragment from yeast cells." Proc. Natl. Acad. Sci. USA 85:8678-8682 (Exhibit J).
Jiang, W., et al. (1995) "Intracellular interference of tick-borne flavivirus infection by using a single-chain antibody fragment delivered by recombinant Sindbis virus." J. Virol. 69:1044-1049 (Exhibit K).
Levine, B., et al. (1996) "Bcl-2 protects mice against fatal alphavirus encephalitis." Proc. Natl. Acad. Sci. USA 93:4810-4815 (Exhibit L).
Nesbit, M., et al. (1992) "Production of a functional monoclonal antibody recognizing human colorectal carcinoma cells from a baculovirus expression system." J. Immunol. Method 151:201-208 (Exhibit M).
Piper, R.C., et al. (1992) "The efficient intracellular sequestration of the insulin-regulatable glucose transporter (GLUT-4) is conferred by the NH.sub.2 terminus." J. Cell Biol. 117:729-743 (Exhibit N).
Poul, M.A., et al. (1995) "Cassette baculovirus vectors for the production of chimeric, humanized, or human antibodies in insect cells." Eur. J. Immunol. 25:2005-2009 (Exhibit O).
Schlesinger, S. (1993) "Alphaviruses--vectors for the expression of heterologous genes." TIBTECH 11: 18-22 (Exhibit P).
Xiong, C., et al. (1989) "Sindbis virus: an efficient, broad host range vector for gene expression in animal cells." Science 243: 1188-1191 (Exhibit Q).

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