Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1978-04-10
1980-11-25
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
424 12, 260112B, G01N 3316, A61K 4300, A61K 3900
Patent
active
042358647
ABSTRACT:
This invention includes an antigenic conjugate of ecgonine and a carrier which elicits anti-benzoylecgonine (cocaine metabolite) serum useful for the detection of cocaine metabolites in human organs and body fluids by immunoassay. The invention also includes the method of producing the anti-benzoylecgonine serum, the immunoassay method and composition including the anti-benzoylecgonine serum and a labeled benzoylecgonine and a non-labeled benzoylecgonine.
The invention also includes a composition comprising a plurality of antigenic conjugates which elicit a multivalent anti-serum capable of complexing a plurality of antigens in a multiple immunoassay detection method. The invention includes the method of producing the multivalent anti-serum and an immunoassay method employing the multivalent anti-serum. The invention further includes a composition comprising the multivalent anti-serum and a plurality of labeled antigens and non-labeled antigens.
REFERENCES:
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patent: 3966764 (1976-06-01), Goldstein et al.
patent: 4041040 (1977-08-01), Christenson et al.
patent: 4045420 (1977-08-01), Soffer et al.
patent: 4071522 (1978-01-01), Christenson et al.
patent: 4102979 (1978-07-01), Christenson
Cleeland et al, Clin. Chem., vol. 22., No. 6, 1976, pp. 712-725.
Mule et al, Clin. Chem., vol. 21, No. 1, 1975, pp. 81-86.
Usategui-Gomez et al, Clin. Chem., vol. 21, No. 10, 1975, pp. 1378-1382.
Davidow Bernard
Kaul Balkrishena
Millian Stephen J.
Clarke Dennis P.
Nucker Christine M.
Padgett Benjamin R.
Research Corporation
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