Simultaneous imaging of cardiac perfusion and a vitronectin...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S001110, C424S001650, C424S001690, C534S014000, C548S303100

Reexamination Certificate

active

06838074

ABSTRACT:
The present invention describes a method of concurrent imaging in a mammal comprising:a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; andb) concurrently detecting the vitronectin receptor targeted imaging agent bound at the vitronectin receptor and the perfusion imaging agent; andc) forming an image from the detection of said vitronectin targeted imaging agent and said perfusion imaging agent.

REFERENCES:
patent: 4248802 (1981-02-01), Kuntz
patent: 4765971 (1988-08-01), Wester et al.
patent: 4859777 (1989-08-01), Toner
patent: 4988827 (1991-01-01), Bergstein et al.
patent: 5028699 (1991-07-01), Iqbal et al.
patent: 5064956 (1991-11-01), Kruper, Jr.
patent: 5087440 (1992-02-01), Cacheris et al.
patent: 5155215 (1992-10-01), Ranney
patent: 5281704 (1994-01-01), Love et al.
patent: 5350837 (1994-09-01), Bridger et al.
patent: 5382654 (1995-01-01), Lyle et al.
patent: 5412148 (1995-05-01), Keana
patent: 5417959 (1995-05-01), Wallace
patent: 5520904 (1996-05-01), Nosco et al.
patent: 5527521 (1996-06-01), Unger
patent: 5547656 (1996-08-01), Unger
patent: 5556939 (1996-09-01), Flanagan et al.
patent: 5567411 (1996-10-01), Keana et al.
patent: 5650134 (1997-07-01), Albert et al.
patent: 5679810 (1997-10-01), Love et al.
patent: 5744120 (1998-04-01), Edwards et al.
patent: 5750088 (1998-05-01), Sworin et al.
patent: 5760028 (1998-06-01), Jadhav et al.
patent: 5760191 (1998-06-01), Snow et al.
patent: 5769080 (1998-06-01), Unger et al.
patent: 5773024 (1998-06-01), Unger et al.
patent: 5801228 (1998-09-01), Hollister et al.
patent: 5804161 (1998-09-01), Long et al.
patent: 5879659 (1999-03-01), Edwards et al.
patent: 6026317 (2000-02-01), Verani
patent: 6146657 (2000-11-01), Unger et al.
patent: 6186628 (2001-02-01), Van de Velde
patent: 6194415 (2001-02-01), Wheeler et al.
patent: 6198532 (2001-03-01), Cabib et al.
patent: 6207107 (2001-03-01), Debrauwere et al.
patent: 6207464 (2001-03-01), Karandikar et al.
patent: 6208886 (2001-03-01), Alfano et al.
patent: 6211626 (2001-04-01), Lys et al.
patent: 6212425 (2001-04-01), Irion et al.
patent: 6216540 (2001-04-01), Nelson et al.
patent: 6217848 (2001-04-01), Achilefu et al.
patent: 6217869 (2001-04-01), Meyer et al.
patent: 6219575 (2001-04-01), Nemati
patent: 6219577 (2001-04-01), Brown, III et al.
patent: 6223071 (2001-04-01), Lundahl et al.
patent: 6225333 (2001-05-01), Rodgers et al.
patent: 6229048 (2001-05-01), Mazur et al.
patent: 6232613 (2001-05-01), Silfvast et al.
patent: 6233481 (2001-05-01), Lawandy
patent: 6238392 (2001-05-01), Long
patent: 6238426 (2001-05-01), Chen
patent: 6245811 (2001-06-01), Horrobin et al.
patent: 6248117 (2001-06-01), Blatter
patent: 6248727 (2001-06-01), Zeimer
patent: 6248734 (2001-06-01), Meadows et al.
patent: 6248741 (2001-06-01), Wheeler et al.
patent: 6254852 (2001-07-01), Glajch et al.
patent: 20020106325 (2002-08-01), Carpenter, Jr.
patent: 20030103898 (2003-06-01), Carpenter, Jr.
patent: 0107734 (1987-07-01), None
patent: 0727225 (1996-08-01), None
patent: WO9114460 (1991-10-01), None
patent: WO9217215 (1992-10-01), None
patent: WO9733627 (1997-09-01), None
Antunes, M.L. et al:, “Diagnosis of Right Ventricular Acute Myocardial Infarction by Dual Isotope Thallium-201 and Indium-111 Antimyosin SPECT Imaging”, Am. J. Cardiol., 70, pp. 426-431 (1992).
Ashton, P.R. et al.,“Amino Acid Derivatives of β-Cyclodextrin”, J. Org. Chem., 61, pp. 903-908 (1996).
Bakker, W.H. et al., [111In-DTPA-D-Phe1]-octreotide, a Potential Radiopharmaceutical for Imaging of Somatostatin Receptor-Positive Tumors: Synthesis, Radiolabeling and In Vitro Validation, Life Sciences, vol. 49, pp. 1583-1591 (1991).
Baraldi, P.G. et al., “Synthesis, Solvolytic Stability and Cytotoxicity of a Modified Derivative of CPzl, a Pyrazole Analog of Alkylation Subunit of the Antitumor Agent CC-1065: Effect of the Nitrogen Substitution on the Functional Reactivity”, II Farmaco, vol. 52 (12), pp. 717-723 (1997).
Bousquet, J. et al., “Gd-DOTA: Characterization of a New Paramagnetic Complex”, Radiology, 166, pp. 693-698 (1988).
Brechbiel, M.W. et al., “Backbone-Substituted DTPA Ligands for90Y Radioimmunotherapy”, Bioconjugate Chem., 2, pp. 187-194 (1991).
Brechbiel, M.W. et al., “Synthesis of C-Functionalized trans-Cyclohexyldiethylenetriaminepenta-acetic Acids for Labeling of Monoclonal Antibodies with the Bismuth-212 α-Particle Emitter”, J. Chem. Soc. Perkin Trans., 1, 1173-1178 (1992).
Brinkley, M., “A Brief Survey of Methods for Preparing Protein Conjugates with Dyes, Haptens, and Cross-Linking Reagents”, Bioconjugate Chem., 3, pp. 2-13 (1992).
Coker, M.L. et al., “Myocardial matrix metalloproteinase activity and abundance with congestive heart failure”, Am. J. Physiol., vol. 274, pp. H1516-H1523 (1998).
Deshpande, S.V. et al., “Yittrium-90-Labeled Monoclonal Antibody for Therapy: Labeling by a New Macrocyclic Bifunctional Chelating Agent”, J. Nucl. Med., 31, pp. 473-479 (1990).
Folkman, J., “Angiogenesis in cancer, vascular, rheumatoid and other disease”, Nature Medicine, vol. 1, No. 1, pp. 27-31 (1995).
Friedlander, M. et al., “Definition of Two Angiogenic Pathways by Distinct αvIntegrins”, Science, vol. 270, pp. 1500-1502 (1995).
Hillel, P.G. et al., “The use of dual-isotope imaging to compare the gastrointestinal transit of food and pancreatic enzyme pellets in cystic fibrosis patients”, Nuclear Medicine Communications, 19, pp. 761-769 (1998).
Hubbuch, A. et al., “Synthese N-geschützter Cysteinsäurederivate und ihrer aktivierten Ester”, Liebigs Ann. Chem., pp. 776-783 (1979).
Krennig, E.P. et al., “Somatostatin Receptor: Scintigraphy and Radionuclide Therapy”, Digestion, 57 (suppl 1), pp. 57-61 (1996).
Krenning, E.P. et al., “Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123L-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients”, European Journal of Nuclear Medicine, vol. 20, No. 8, pp. 716-731 (1993).
Magerstädt, M. et al., “Gd(DOTA): An Alternative to Gd(DTPA) as a T1,2Relaxation Agent for NMR Imaging or Spectroscopy”, Magn. Reson. Med., 3, pp. 808-812 (1986).
Manning, D.D. et al., “Neoglycopolymer Inhibitors of the Selectins”, Tetrahedron, vol. 53, No. 35, pp. 11937-11952 (1997).
McNulty, P.H. et al., “Glycogen depletion contributes to ischemic preconditioning in the rat heart in vivo”, Am. J. Physiol., vol. 271 (6, Pt. 2), pp. H2283-H2289 (1996).
Mousa, S.A. et al., “Recent advances in cell adhesion molecules and extracellular matrix proteins: potential clinical implications”, DDT, vol. 2, No. 5, pp. 187-199 (1997).
Runge, V.M. et al., “MR Imaging of Rat Brain Glioma: Gd-DTPA versus Gd-DOTA”, Radiology, 166, pp. 835-838 (1988).
Samanen, J. et al., “Vascular Indications for Integrin αv Antagonists”, Current Pharmaceutical Design, 3, pp. 545-584 (1997).
Sellke et al., “Angiogenesis in Cardiovascular Disease”, Drugs, 58 (3), pp. 391-396 (1999).
Senger, D.R. et al., “Angiogenesis promoted by vascular endothelial growth factor: Regulation through α1β2and α2β1integrins”, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 13612-13617 (1997).
Srivatsa, S.S. et al., “Selective αvβ3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury . . . ”, Cardiovascular Research, 36, pp. 408-428 (1997).
White, S.A. et al., “Case Report: Spectral Overlap Artifact During Isotope Imaging with Tc-99m and In-111”, Journal of Nuclear Medicine Technology, vol. 12, No. 3, pp. 124-125 (1984).
Youker, K.A. et al., “Time-Dependent Neutrophil β1 and β3 Integrin Expression in the Reperfused Myocardium: Role in Tissue Migration”, Circulation, Supplement I, vol. 1

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Simultaneous imaging of cardiac perfusion and a vitronectin... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Simultaneous imaging of cardiac perfusion and a vitronectin..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Simultaneous imaging of cardiac perfusion and a vitronectin... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3436632

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.