Measuring and testing – Sampler – sample handling – etc.
Reexamination Certificate
2009-07-15
2010-11-16
Williams, Hezron (Department: 2856)
Measuring and testing
Sampler, sample handling, etc.
C073S863310
Reexamination Certificate
active
07832291
ABSTRACT:
A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of the change in the shift in peak wavelength value as a function of time (kon) from the well as the sample is introduced into the well; simultaneously dispensing the sample to the well and aspirating the sample from the well and measuring the change in the shift in peak wavelength value as a function of time (koff) during the simultaneous dispensing and aspirating, and calculating an equilibrium association constant or an equilibrium dissociation constant for the sample from the values of konand koff.
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Gerstenmeier, III John
Jogikalmath Gangadhar
Laing Lance G.
Smith Timothy F.
Frank Rodney T
McDonnell Boehnen & Hulbert & Berghoff LLP
SRU Biosystems Inc.
Williams Hezron
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