Liquid purification or separation – Processes – Chromatography
Reexamination Certificate
2000-03-17
2001-12-04
Therkorn, Ernest G. (Department: 1723)
Liquid purification or separation
Processes
Chromatography
C210S198200
Reexamination Certificate
active
06325940
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a simulated moving bed chromatographic separation system, particularly to a simulated moving bed chromatographic system capable of evaluating the separation performance of the unit packed beds of the system without removing the packed beds from the system.
2. Prior Art
In recent years, the simulated moving bed chromatographic system has been frequently and broadly used for separation or purification of various chemical products such as drugs, pharmaceuticals, agrochemicals, perfumes, sucrose, etc.
In general, the simulated moving bed chromatographic separation system for separating from a feedstock the constituents thereof, such as drugs, pharmaceuticals, agrochemicals, perfumes, sucrose, etc., is provided with a fluid circulating passage through which a liquid (hereunder referred to as “circulating liquids”) flows and which has at least four columns containing separating fillers packed therein, connected in series and endlessly to each other by piping, a desorbing liquid introducing port for introducing the desorbing liquid into the fluid circulating passage, an extract draw-out port for drawing out a circulating liquid containing a larger amount of constituents in the feedstock to be strongly adsorbed on the fillers (hereunder referred to as “extract”), a feedstock introducing port for introducing the feedstock containing the constituents into the fluid circulating passage, and a raffinate draw-out port for drawing out a circulating liquid containing a larger amount of constituents to be weakly adsorbed on the fillers (hereunder referred to as “raffinate”). The desorbing liquid introducing port, extract draw-out port, feedstock introducing port and raffinate draw-out port are arranged in this order on the fluid circulating passage and designed so that their positions may be intermittently shifted without changing this order.
Operating the simulated moving bed chromatographic separation system for a long time causes the fillers in the columns to be deteriorated or the performance of the columns or piping to be reduced due to deposition of impurities on the columns or piping. Therefore, the purity of the strongly adsorptive constituents in the resulting extract or the weakly adsorptive constituents in the resulting raffinate may be lowered.
In such case, prior art simulated moving bed chromatographic separation systems have in general been examined by removing the columns from the fluid circulating passage, mounting the columns one by one on a high-speed chromatographic apparatus and then evaluating the separating performance of the columns.
Thus, the examination operation is complicated, and it takes a long time to know which column is deteriorated.
Furthermore, when the separating performance of the columns evaluated for by the high-speed chromatographic apparatus are again mounted on the fluid circulating passage, the packings or O-rings on the ends of the columns may be damaged, so liquid leakage may occur at the ends of the columns.
SUMMARY OF THE INVENTION
The object of this invention is to provide a simulated moving bed chromatographic separation system free of the problems of prior art simulated moving bed chromatographic systems as mentioned above.
In particular, the object of this invention is to provide a simulated moving bed chromatographic system comprising unit packed columns, which can be examined without removing these columns from the system on whether the deterioration of the system is caused by the columns or not, and, if yes, which column causes the deterioration.
In order to solve the problems as mentioned above, this invention provides the simulated moving bed chromatographic system as follows:
(1) a simulated moving bed chromatographic separation system for separating from a feedstock the constituents thereof, which comprises a fluid circulating passage having the fluid forcibly circulated therethrough and having at least four packed beds filled with separating fillers and connected in series and endlessly to each other; a desorbing liquid introducing port for introducing the desorbing liquid into the fluid circulating passage; an extract draw-out port for drawing out the extract containing a larger amount of a constituent strongly adsorbed on the fillers, of the constituents contained in a feedstock from said fluid circulating passage; a feedstock introducing port for introducing the feedstock into the fluid circulating passage; and a raffinate draw-out port for drawing out the raffinate containing a larger amount of a constituent weakly adsorbed on the fillers, of the constituents, wherein the desorbing liquid introducing port, extract draw-out port, feedstock introducing port and raffinate draw-out port are arranged in this order in the direction of fluid flow on the fluid circulating passage, and designed so that the positions of these ports are successively but intermittently shifted along said fluid circulating passage without changing this order, the system also comprising packed bed performance evaluating means for examining the condition of each of the constituents separated in each of said packed beds, by injecting a standard solution of which the kinds of the constituents contained and their concentrations are known and the desorbing liquid into each of said packed beds; and
(2) a simulated moving bed chromatographic separation system recited in (1) above, which is provided with desorbing liquid injecting means for injecting a desorbing liquid at the inlet side end of the packed beds, a standard solution injecting means for injecting the standard solution at the inlet side end of the packed beds, and a detector means at the outlet side end of the packed beds for detecting the constituents desorbed by the packed beds.
REFERENCES:
patent: 4468331 (1984-08-01), Antle
patent: 4872992 (1989-10-01), Oquendo
patent: 4925567 (1990-05-01), McAleese
patent: 5064539 (1991-11-01), Tanimura
patent: 5198120 (1993-03-01), Masuda
patent: 5223143 (1993-06-01), Masuda
patent: 5391299 (1995-02-01), Masuda
patent: 5434298 (1995-07-01), Negawa
patent: 5434299 (1995-07-01), Negawa
patent: 5470464 (1995-11-01), Priegnitz
patent: 5498752 (1996-03-01), Negawa
patent: 5630943 (1997-05-01), Grill
patent: 5770088 (1998-06-01), Ikeda
Daicel Chemical Industries Ltd.
Therkorn Ernest G.
LandOfFree
Simulated moving bed chromatographic separation system does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Simulated moving bed chromatographic separation system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Simulated moving bed chromatographic separation system will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2582764