Simulated human platelets from red blood cells

Details Simulated human platelets from red blood cells Simulated human platelets from red blood cells

1990-05-24

1991-04-16

Wallen, Thomas

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

Particle count or volume standard or control

436 11, 435 2, G01N 3100, G01N 3348

Patent

active

050082019

ABSTRACT:
Lysable, blood platelet controls are prepared by treating animal red blood cells larger than or within the size range of human blood platelets with a fixing agent for red blood cells for a time sufficient to partially rigidify the red blood cell membrane enabling shrinking to a permanently shrunk condition, subjecting distinct groups of said partially fixed red blood cells to hemolysis wiht a hemolytic agent to partially remove hemoglobin therefrom, the hemolysis of each distinct group of cells removing a different amount of hemoglobin, subjecting the resulting red blood cells to centrifugation to collapse the red blood cell membrane around the hemoglobin remaining in said cells, said distinct group of cells and the extent of hemolysis being selected so as to provide after said centrifugation a mixture of permanently shrunken lysable cells that simulate in number, size and volume distribution the platelets present in human whole blood.

REFERENCES:
patent: 4412004 (1983-10-01), Ornstein et al.
patent: 4436821 (1984-03-01), Ryan
patent: 4698312 (1987-10-01), Wong et al.
patent: 4777139 (1988-10-01), Wong et al.

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