Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Patent
1997-12-02
2000-02-08
Redding, David A.
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
4352973, 4352974, 4352982, C12M 300
Patent
active
060227338
ABSTRACT:
The invention relates to a system and method for assessing simulated biological dissolution of a pharmaceutical formulation and absorption of a pharmaceutically active compound therefrom. The system comprises a dissolution chamber and a cell culture chamber. Within the dissolution chamber, the dissolution profile of the pharmaceutical formulation (or drug) is determined. Within the cell culture chamber, the pharmaceutically active compound may be absorbed and transported by a cell monolayer. The cell culture chamber includes a tubular filter which is permeable to medium and capable of supporting the cell monolayer on its interior surface. Insertion of the filter into the cell culture chamber housing forms an apical chamber interior of the filter, and a basal chamber between the filter and the wall of the housing. The filter rotates about an axis within the housing substantially parallel to the direction of media flow through the cell culture chamber. The medium flowing from the dissolution chamber contains the pharmaceutical formulation and is provided to the apical chamber. The rate of appearance of the pharmaceutically active compound in the medium outflowing from the basal chamber may be analysed to determine absorption of the pharmaceutically active compound.
REFERENCES:
patent: 4667504 (1987-05-01), Hobson
patent: 4681858 (1987-07-01), Chaudhari et al.
patent: 5026650 (1991-06-01), Schwartz et al.
patent: 5153131 (1992-10-01), Wolf et al.
patent: 5153132 (1992-10-01), Goodwin et al.
patent: 5153133 (1992-10-01), Schwartz et al.
patent: 5155035 (1992-10-01), Schwartz et al.
patent: 5518915 (1996-05-01), Naughton et al.
patent: 5525305 (1996-06-01), Minekus et al.
patent: 5589649 (1996-12-01), Brinker et al.
Chiou, W.L., Determination of drug permeability in a flat or distended stirred intestine, Int. J. Clin. Pharm. Ther., 1994; 32(9):474-482.
Grundy et al., Nifedipine Gits In-Vivo/In-Vitro Correlation, Proc. Intern. Symp. Control Rel. Bioact. Mater., 1996;23:18-19.
Katori et al., Estimation of Agitation Intensity in the GI Tract in Humans and Dogs Based on in Vitro/in Vivo Correlation, 1995;12:237-243.
Anderson Keith Edward
Tam Yun K.
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