Simplified thioester and isostere analogs of oleoyl coenzyme a a

Details Simplified thioester and isostere analogs of oleoyl coenzyme a a Simplified thioester and isostere analogs of oleoyl coenzyme a a

1990-03-29

1991-10-01

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549372, 514824, A61K 31335, C07D31906

Patent

active

050534262

ABSTRACT:
New thioester and ester, amide and ketone isostere analogs of oleoyl coenzyme A, useful as antiatherosclerotic agents, are provided. The compounds have the formula: ##STR1## wherein A is selected from the group consisting of ##STR2## Y is selected from the group consisting of --S--, --O--, --NH-- and (--CH.sub.2 --).sub.n wherein n=1 to 4; and Z is selected from the group consisting of alkyl (C.sub.1 -C.sub.6), ##STR3## wherein R=Hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 acyl, and ##STR4##

REFERENCES:
Bonner et al., J. Biol. Chem., 247 (10), 3123-3133 (1972).

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