Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2005-03-29
2005-03-29
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C560S255000
Reexamination Certificate
active
06872748
ABSTRACT:
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions that have such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for preventing, alleviating or treating pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neutopathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease or urgent urinary incontinence.
REFERENCES:
patent: 6476076 (2002-11-01), Lee et al.
Vanilloid (Capsaicin) Receptors & Mechanisms; A. Szallashi, et al., Vol. 51, #2, Pharmacological Reviews, pp. 159-211.
Capsaicin-Induced Ion Fluxes in Dorsal Root Ganglion Cells In Culture, JN Wood et al, The Journal of Neuroscience, Sep. 1988, 8(9): 3208-3220.
The capsaicin receptor: a heat-activated ion channel in the pain pathway; MJ Caterina et al., Nature:vol. 389: Oct. 23, 1997, pp. 816-824.
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli, M.Tominaga et al., Neuron, vol. 21, 531-543, Sep. 1998.
Impaired Nociception & Pain Sensation in Mice Lacking the Capsaicin Receptor, MJ Caterina et al., Apr. 14, 2000, vol. 288 Science, pp. 306-313.
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia, Letters to Nature, vol. 405, May 11, 2000, pp. 183-187.
3-Acyloxy-2-phenalkylpropyl Amides & Esters of Homovanillic Acid as Novel Vanilloid Receptor Agonists, Bioorganic & Medicinal Chemistry Letters 9 (1999) 2909-2914.
Capsaicin-like agonists, R. Wrigglesworth et al., Drugs of the Future 1998, 23(5): 531-538.
Anderson Kill & Olick PC
Digital Biotech Co., Ltd.
Raymond Richard L.
Tucker Zachary C.
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