Simplified process of forming crystalline ceftazidime pentahydra

Details Simplified process of forming crystalline ceftazidime pentahydra Simplified process of forming crystalline ceftazidime pentahydra

1984-07-02

1986-10-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, C07D50146, A61K 31545

Patent

active

046160809

ABSTRACT:
Ceftazidime pentahydrate in crystalline form is provided in a one-step process comprising acidic removal of protecting groups from an amino-protected and carboxy-protected ceftazidime, separation of aqueous phase after addition of a water-immiscible organic solvent, and precipitation of pentahydrate by adjusting pH of aqueous phase from about 3.5 to about 4.5.

REFERENCES:
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4329453 (1982-05-01), Brodie et al.
patent: 4467086 (1984-08-01), Miller
patent: 4537959 (1985-08-01), Chou
Wiberg "Laboratory Technique in Organic Chemistry", 1960, McGraw-Hill, pp. 179 and 180.

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