Simplified process for the degradation of steroid-C-22-carboxyli

Details Simplified process for the degradation of steroid-C-22-carboxyli Simplified process for the degradation of steroid-C-22-carboxyli

1982-06-24

1984-02-21

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603973, 2603974, C07J 900

Patent

active

044329059

ABSTRACT:
The degradation of steroid-C22-carboxylic acids to the C20-carbonyl steroids is carried out in simplified form and preferably without isolating intermediate reaction products by using 17(20)-steroid-22-carboxylic acids as starting material and directly transforming them into the 20-carbonyl compound through their respective acid halides by the Curtius degradation or by carboxy-inversion degradation. The acetyl substituent thus formed in C17 of the steroid compounds is present in the pharmacologically required configuration.

REFERENCES:
patent: 4252732 (1981-02-01), Krbechek et al.
patent: 4255345 (1981-03-01), Krbechek

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