Simplified method for the preparation of human lymphokine activa

Details Simplified method for the preparation of human lymphokine activa Simplified method for the preparation of human lymphokine activa

1987-04-27

1989-02-28

Richman, Barry S.

Surgery

Blood drawn and replaced or treated and returned to body

Constituent removed from blood and remainder returned to body

514 2, 514 21, 530351, 2103601, 210927, 435 68, A61M 3700, A61K 3702, A61K 4505

Patent

active

048081515

ABSTRACT:
A lymphocyte-containing white blood cell fraction obtained by standard leukapheresis, elutriation leukapheresis or standard centrifugation can be used for production of lymphokine activated killer cells by incubation with IL-2. Removal of red blood cells and granulocytes by centrifugation on ficoll is not necessary.

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Muul et al., (1987), Development of an Automated Closed System for Generation of Human Lymphokine-Activated Killer (LAK) Cells for Use in Adoptive Immunotherapy, J. Immunol. Methods, 101, 171-181.
Muul et al., "Large Scale Production of Human Lymphokine Activated Killer Cells for Use in Adoptive Immunotherapy", Journal of Immunological Methods, 88:265-275, (1986).
Wall Street Journal, Apr. 9, 1987, "Further Success in Using Interleukin-2 to Treat Cancer Reported by 2 Teams".
"Haemonetics Components for LAK Cell Processing", Bulletin of Haemonetics Corporation, one page.
"V50 Ficoll-Hypaque Procedure", Bulletin of Haemonetics Corporation, two pages.

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