Simplified in-vitro interferon production

Details Simplified in-vitro interferon production Simplified in-vitro interferon production

1981-12-30

1984-12-25

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

435 68, 260112R, A61K 4502, C12P 2100

Patent

active

044903570

ABSTRACT:
Interferon is produced in-vitro from whole blood, obtainable from animals or humans including blood from corpses or retroplacental blood, in a simplified non-critical process preferably carried out in a sterile system of interconnected plastic bags. The blood is stabilized and innoculated with an interferon inducer before culturing in an incubator. This results in interferon containing blood useful directly for transfusions or further processable to obtain a variety of therapeutic interferon containing preparations including plasma, serum and albumin in accordance with disclosed phases of this invention. Interferon carrying plasma is thus separated and treated further to isolate interferon carrying serum or albumin, if desired. In-vivo innoculation to produce antibodies before taking blood provides improved disease fighting characteristics in the derived product. Steps are provided for purification of the products such as removal of residual inducers or the treatment for presence of suspected hepatitis virus, etc.

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Mogensen, K., et al., Pharm. Ther. A., vol. 1, pp. 369-381, 1977.
Interferons and Their Actions, W. E. Stewart II, editor, Havell, "Cellular Regulatory Mechanisms Controlling Synthesis of Interferons", pp. 37-38, 1977.

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