Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2008-05-27
2008-05-27
Berman, Jack I. (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S283000, C250S287000, C250S288000, C250S297000
Reexamination Certificate
active
07378649
ABSTRACT:
In some embodiments, a method of optimizing operating parameters of an analytical instrument (e.g. lens voltages of a mass spectrometer) includes steps taken to minimize the method duration in the presence of substantial instrument noise and/or drift. Some methods include selecting a best point between a default instrument parameter set (vector) and a most-recent optimum parameter set; building a starting simplex at the selected best point location in parameter-space; and advancing the simplex to find an optimal parameter vector. The best simplex points are periodically re-measured, and the resulting readings are used to replace and/or average previous readings. The algorithm convergence speed may be adjusted by reducing simplex contractions gradually. The method may operate using all-integer parameter values, recognize parameter values that are out of an instrument range, and operate under the control of the instrument itself rather than an associated control computer.
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Newton Kenneth R.
Specht August
Berman Jack I.
Fishman Bella
Logie Michael J
Popovici Andrei D.
Varian Inc.
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