Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-03-26
1999-07-20
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 435385, G01N 33574, G01N 3353, C12N 506
Patent
active
059255307
ABSTRACT:
This invention relates to identification of a new key marker, namely, 9-O-Acetylated Sialoglycoconjugate with the help of a known 9-O-Acetylsialic acid binding lectin, AchatininH useful for the detection of minimal residual disease (MRD) and prediction of relapse by a lymphoproliferation assay in acute lymphoblastic leukaemia (ALL).
REFERENCES:
Sen G., et al. O-Acetylated Sialic Acid as a Distinct Marker for Differentiation Between Several Leukemia Erythrocytes (1994) Molecular Cellular Biochemistry 136: 65-70.
Tsai C-M, et al. A Waldenstrom Macroglobulin that is Both a Cold Agglutinin and a Cryoglobulin Because it Binds N-Acetylneuraminosyl (1977) Proc. Nat'l. Acad. Sci. 74: 4591-4594.
Sen G., et al. The Specificity of the Binding Site of Achatinin H, a Sialic Acid-Binding Lectin from Achatina fulica (1995) Carbohydrate Research 268: 115-125.
Bhattacharya Dilip Kumar
Mandal Chitra
Sinha Diviya
Scheiner Toni R.
The Council of Scientifiic and Industrial Research
White John P.
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