Chemistry: analytical and immunological testing – Biological cellular material tested
Patent
1987-10-02
1989-06-06
Richman, Barry S.
Chemistry: analytical and immunological testing
Biological cellular material tested
436805, 436811, G01N 3348
Patent
active
048371637
ABSTRACT:
The invention provides a simple, non-invasive method of screening malignant hyperthermia using a few milliliters of blood drawn from an individual into an acid-citrate anti-coagulant. When blood preservation is not needed, the blood specimen is stored for several hours at room temperature, after which a small amount of blood is taken into a cuvette with the optical path of 0.1 mm. Then, by measuring optical densities at wavelengths of 542 and 578 nm, the susceptibility for malignant hyperthermia can be determined. When a blood specimen has to be shipped to a distant screening center, the specimen can be stored in a styroform container at 0.degree.-4.degree. C. with either wet ice or artificial coolant and delivered by an express carrier service. Upon arrival, optical measurement is done in a similar fashion.
REFERENCES:
patent: 4260678 (1981-04-01), Lepp et al.
patent: 4362645 (1982-12-01), Hof et al.
patent: 4543359 (1985-09-01), Ellis et al.
patent: 4600696 (1986-07-01), Solomons
"Calcium-Induced Ca.sup.+2 Release from Sarcoplasmic Reticulum of Pigs Susceptible to Malignant Hyperthermia", Ohnishi et al., FEBS, 0771, 9-1983, vol. 163, No. 1, pp. 103-107.
"Abnormal Membrane Properties of the Sarcoplasmic Reticulum of Pigs Susceptible to Malignant Hyperthermia", Ohnishi et al., Archives of Biochem. and Biophysics, vol. 247, 6-1986, pp. 294-301.
"Effects of Halothane, Caffeine, Dantrolene, and Tetracaine on the Calcium Permeability of Skeletal Sarcoplasmic Reticulum of Malignant Hyperthermic Pigs", Ohnishi, Biochimica et Biophisica Acta, 897, pp. 261-268.
Richman Barry S.
Wallen T. J.
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