Simian virus recombinant that directs the synthesis of hepatitis

Details Simian virus recombinant that directs the synthesis of hepatitis Simian virus recombinant that directs the synthesis of hepatitis

1981-09-22

1984-04-10

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435172, 435317, 435238, 424 89, C12P 2100, C12N 1500, C12N 100, C12N 706

Patent

active

044422059

ABSTRACT:
A process for producing a recombinant between simian virus 40 (SV40) and hepatitis B virus (HBV) is given. When tissue culture cells are infected with the recombinant, hepatitis B surface antigen is produced. Because a single cloned gene is used, the surface antigen produced is homogeneous and can be produced without conventional dependence on human sera. The antigen is excreted into the culture medium as 22 nm particles with the same physical properties, antigenic composition and constituent polypeptides as those found in the sera of patients with Type B hepatitis. The antigen is useful for the preparation of vaccines.

REFERENCES:
Moriority et al, PNAS USA vol. 78, pp. 2606-2610, Apr. 1981.
Burnell et al, Nature, vol. 279, pp. 43-47 (May 1979).
Dubois et al, Proc. Natl. Acad. Sci. USA vol. 77, No. 8, pp. 4549-4553 (Aug. 1980).
Charnay et al, Nature, vol. 286, pp. 893-895 (Aug. 1980).
Sninsky et al, Nature, vol. 279, pp. 346-348 (May 1979).
Valenzuela et al, Nature, vol. 280, pp. 815-819 (1979).
Mulligan et al, Nature, vol. 277, pp. 108-114 (Jan. 1979).
Goff et al, J. Mol. Biol., vol. 133, pp. 359-383 (1979).

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