Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2003-08-19
2009-10-27
Parkin, Jeffrey S. (Department: 1648)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S325000, C435S455000, C536S023720, C514S04400A
Reexamination Certificate
active
07608422
ABSTRACT:
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.
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Myers, G., et al., Human Retroviruses and AIDS 1995: A compilation and analysis of nucleic acid and amino acid sequences, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, section IB (HIV-2/SIV gag nucleotide sequence alignment).
Benson, J., et al., 1998, Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIVmac251: dependence on route of challenge exposure, J. Virol. 72(5):4170-4182.
Parkin Jeffrey S.
The United States of America as represented by the Secretary of
Townsend and Townsend / and Crew LLP
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