Simethicone containing pharmaceutical compositions

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills

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Details

424461, 424462, 424441, A61K 926, A61K 952, A61K 31765

Patent

active

059809442

ABSTRACT:
A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of granules of diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier coat on the granules which is substantially impermeable to simethicone.

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J. Alfred Rider, An Improved Simethicone Antacid Tablet, pp. 1033-1038 (1981).
F. Maksoud, S.A. Said and M. Gourab, "Simethicone Use in Antacid Medications", pp. 35 and 36 (1976).
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CA93(14):138018p, Uniform Beadlike Particles Forming a Powder Surpuriya (1980).
CA90(17):132533u, Interaction of Digoxin with Activated Dimethicone and Other Antacid Constituents (1979).
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C71-S36634, Flatulence Treatment with Antifoaming--Comon (1974).
C75-W80496, Medicaments for Treating Nervous Hyperacidity, Etc.--Contg. a Psychosedative, an Antacid, and an Antiflatuent (1975).

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